Structure−Activity Relationships of the Didemnins 1,2
✍ Scribed by Sakai, Ryuichi; Rinehart, Kenneth L.; Kishore, Vimal; Kundu, Bijoy; Faircloth, Glynn; Gloer, James B.; Carney, John R.; Namikoshi, Michio; Sun, Furong; Hughes,, Robert G.; Grávalos, Dolores García; de Quesada, Teresa García; Wilson, George R.; Heid, Richard M.
- Book ID
- 120661074
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 459 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The 2-aminoalcohol series of immunosuppressants showed a bell-shaped relationship between the activity and the carbon number. The (R)-isomers were more potent than the (S)isomers, and (R)-2-aminohexadecanol displayed comparably activity to a potent immunosuppressant, FTY720.
## Abstract Naphthoquinone derivatives are under investigation as potential therapeutic agents. Some such compounds are known, however, to be toxic to both animals and humans. Many naphthoquinone derivatives are haemolytic agents, while others cause necrosis of tubular epithelial cells. In the pres