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2-aminoalchohol immunosuppressants: Structure-activity relationships

✍ Scribed by Ryoji Hirose; Norimitsu Hamamichi; Yuuki Kitao; Tohru Matsuzaki; Kenji Chiba; Tetsuro Fujita

Book ID: 104364633
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 168 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(96)00487-8

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✦ Synopsis

The 2-aminoalcohol series of immunosuppressants showed a bell-shaped relationship between the activity and the carbon number. The (R)-isomers were more potent than the (S)isomers, and (R)-2-aminohexadecanol displayed comparably activity to a potent immunosuppressant, FTY720.

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