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Structure–Activity Relationships of Precursors and Analogs of Natural 3-Enoyl-tetramic Acids

✍ Scribed by Bertram Barnickel; Frances Bayliffe; Randi Diestel; Karl Kempf; Sabine Laschat; Steffen Pachali; Florenz Sasse; Andrea Schlenk; Rainer Schobert


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
247 KB
Volume
7
Category
Article
ISSN
1612-1872

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Following up on the observation that the dynorphin analog [Pro(3)]Dyn A(1-11)-NH(2) 2 possesses high affinity and selectivity for the kappa opioid receptor, a number of related peptides were prepared and characterized by radioligand binding and [(35)S]GTPgammaS assays. While incorporation of 2-azeti