Structure–activity relationships of carboxymethylpullulan-peptide-doxorubicin conjugates—systematic modification of peptide spacers

✍ Scribed by Hideo Nogusa; Toshiro Yano; Nobukazu Kashima; Keiji Yamamoto; Satoshi Okuno; Hiroshi Hamana

• Book ID: 104364960
• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 117 KB
• Volume: 10
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(99)00678-2

✦ Synopsis

A series of carboxymethylpullulan (CMPul)-doxorubicin (DXR) conjugates bound by peptide spacers of different compositions and lengths were prepared and evaluated for their in vivo antitumor effects. Systematic study of the peptide spacers indicated that CMPul-DXR conjugates bound via appropriate dipeptide spacers were more potent than DXR.