𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Structure–activity relationships of benzimidazole-based selective inhibitors of the mitogen activated kinase-5 signaling pathway

✍ Scribed by Patrick T. Flaherty; Ishveen Chopra; Prashi Jain; Darlene Monlish; Jane Cavanaugh

Book ID
108072925
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
236 KB
Volume
18
Category
Article
ISSN
0968-0896

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Structure-based quantitative structure-a
Structure-based quantitative structure-activity relationship studies of checkpoint kinase 1 inhibitors
✍ Juan Du; Lili Xi; Beilei Lei; Jing Lu; Jiazhong Li; Huanxiang Liu; Xiaojun Yao 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 528 KB

## Abstract Structure‐based quantitative structure‐activity relationship (QSAR) studies on a series of checkpoint kinase 1 (Chk1) inhibitors were performed to find the key structural features responsible for their inhibitory activity. Molecular docking was employed to explore the binding mode of al

Constitutive activation of the mitogen-a
Constitutive activation of the mitogen-activated protein kinase pathway impairs vitamin D signaling in human prostate epithelial cells
✍ Zhentao Zhang; Pavlo Kovalenko; Min Cui; Marsha DeSmet; Steven K. Clinton; James 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 341 KB

## Abstract We studied the effect of prolonged activation of mitogen‐activated protein kinase (MAPK) signaling on 1,25 dihydroxyvitamin D (1,25(OH)~2~D~3~) action in the immortalized human prostate epithelial cell line RWPE1 and its Ki‐Ras transformed clone RWPE2. 1,25(OH)~2~D~3~‐treatment caused g