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Structure–activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent

✍ Scribed by Akama, Tsutomu; Virtucio, Charlotte; Dong, Chen; Kimura, Richard; Zhang, Yong-Kang; Nieman, James A.; Sharma, Rashmi; Lu, Xiaosong; Sales, Marcelo; Singh, Rajeshwar; Wu, Anne; Fan, Xiao-Qing; Liu, Liang; Plattner, Jacob J.; Jarnagin, Kurt; Freund, Yvonne R.


Book ID
120344816
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
534 KB
Volume
23
Category
Article
ISSN
0960-894X

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A series of boron-containing benzoxaborole compounds was designed and synthesized for a structureactivity relationship investigation surrounding 7-(HOOCCH 2 CH 2 )-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1) with the goal of discovering a new antimalarial treatment. Compound 1 demonstrates the best