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Discovery and structure–activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents

✍ Scribed by Akama, Tsutomu; Dong, Chen; Virtucio, Charlotte; Freund, Yvonne R.; Chen, Daitao; Orr, Matthew D.; Jacobs, Robert T.; Zhang, Yong-Kang; Hernandez, Vincent; Liu, Yang; Wu, Anne; Bu, Wei; Liu, Liang; Jarnagin, Kurt; Plattner, Jacob J.


Book ID
121288669
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
626 KB
Volume
23
Category
Article
ISSN
0960-894X

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A series of boron-containing benzoxaborole compounds was designed and synthesized for a structureactivity relationship investigation surrounding 7-(HOOCCH 2 CH 2 )-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1) with the goal of discovering a new antimalarial treatment. Compound 1 demonstrates the best