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Structure−Activity Relationships of 2, N 6 ,5‘-Substituted Adenosine Derivatives with Potent Activity at the A 2B Adenosine Receptor

✍ Scribed by Adachi, Hayamitsu; Palaniappan, Krishnan K.; Ivanov, Andrei A.; Bergman, Nathaniel; Gao, Zhan-Guo; Jacobson, Kenneth A.


Book ID
118152777
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
424 KB
Volume
50
Category
Article
ISSN
0022-2623

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A series of phenyl-substituted N 6 -phenyladenosines and N 6 -phenyl-5′-N-ethylcarboxamidoadenosines were synthesized and tested at adenosine receptor subtypes. EC 50 values were determined for cyclic AMP production in CHO cells expressing human A 2B receptors. Binding affinities were determined for