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Agonist activity of 2- and 5′-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1− and A2−adenosine receptors coupled to adenylate cyclase

✍ Scribed by John W. Daly; William L. Padgett


Book ID
115783026
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
580 KB
Volume
43
Category
Article
ISSN
0006-2952

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A series of phenyl-substituted N 6 -phenyladenosines and N 6 -phenyl-5′-N-ethylcarboxamidoadenosines were synthesized and tested at adenosine receptor subtypes. EC 50 values were determined for cyclic AMP production in CHO cells expressing human A 2B receptors. Binding affinities were determined for