𝔖 Bobbio Scriptorium
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Structure–activity relationships in β-defensin peptides

✍ Scribed by Karen Taylor; Perdita E. Barran; Julia R. Dorin

Publisher
Wiley (John Wiley & Sons)
Year
2007
Tongue
English
Weight
188 KB
Volume
90
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The β‐defensins comprise a large family of small cationic antimicrobial peptides widely distributed in plants, mammals and insects. These cysteine rich peptides display multifunctional properties with implications as potential therapeutic agents. Recent research has highlighted their role in both the innate and adaptive immune systems as well as being novel melanocortin ligands. Studies investigating structure and function provide an insight into the molecular basis of their immunological properties. © 2007 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90: 1–7, 2008.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at [email protected]

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✍ J. Hlavacek; J. Koudelka; J. Jarv 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 263 KB

The structure-activity relationships for selected peptide juvenoids of the general formula \(\mathrm{R}^{1}-\mathrm{CONHCH}\left(\mathrm{R}^{3}\right) \mathrm{CONH}-\mathrm{C}_{6} \mathrm{H}_{4}-\mathrm{R}^{2}\) were analyzed by using linear free energy relationships. It was found that both the hydr