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Structure–activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH

✍ Scribed by Sivapriya Kirubakaran; Suresh Kumar Gorla; Lisa Sharling; Minjia Zhang; Xiaoping Liu; Soumya S. Ray; Iain S. MacPherson; Boris Striepen; Lizbeth Hedstrom; Gregory D. Cuny


Book ID
113496597
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
777 KB
Volume
22
Category
Article
ISSN
0960-894X

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## Abstract Structure‐based quantitative structure‐activity relationship (QSAR) studies on a series of checkpoint kinase 1 (Chk1) inhibitors were performed to find the key structural features responsible for their inhibitory activity. Molecular docking was employed to explore the binding mode of al