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Structure–activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells

✍ Scribed by Akiyuki Ikedo; Ichiro Hayakawa; Takeo Usui; Sayaka Kazami; Hiroyuki Osada; Hideo Kigoshi

Book ID: 104004709
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 488 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.07.111

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✦ Synopsis

Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S 3 cells was investigated. Compared to glaziovianin A, the O 7 -allyl derivative was found to be more cytotoxic against HeLa S 3 cells and a more potent M-phase inhibitor.

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