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Antitumor Potential of Crown Ethers: Structure−Activity Relationships, Cell Cycle Disturbances, and Cell Death Studies of a Series of Ionophores

✍ Scribed by Marjanović, Marko; Kralj, Marijeta; Supek, Fran; Frkanec, Leo; Piantanida, Ivo; Šmuc, Tomislav; Tušek-Božić, Ljerka

Book ID: 118026540
Publisher: American Chemical Society
Year: 2007
Tongue: English
Weight: 226 KB
Volume: 50
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm061162u

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Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S 3 cells was investigated. Compared to glaziovianin A, the O 7 -allyl derivative was found to be more cytotoxic against HeLa S 3 cells and a more potent M-phase inhibitor.