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Structure–Activity Relationship Study of 16 a-Thiocamptothecins: an Integrated In Vitro and In Silico Approach

✍ Scribed by Dr. Cristian Samorì; Dr. Giovanni L. Beretta; Dr. Greta Varchi; Dr. Andrea Guerrini; Dr. Simone Di%emsp14;Micco; Dr. Serena Basili; Prof. Giuseppe Bifulco; Prof. Raffaele Riccio; Prof. Stefano Moro; Dr. Ezio Bombardelli; Dr. Franco Zunino; Dr. Gabriele Fontana


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
507 KB
Volume
5
Category
Article
ISSN
1860-7179

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The expiratory bradypnea indicative of upper airway irritation in mice was evaluated during a 15-min oronasal exposure to increasing concentrations of sixteen aliphatic amines. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice ( R D ~~) was calculated for each te