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Structure–activity relationship studies with (±)-nantenine derivatives for α1-adrenoceptor antagonist activity

✍ Scribed by Bachtiar Indra; Kimihiro Matsunaga; Osamu Hoshino; Masaji Suzuki; Hiromichi Ogasawara; Yasushi Ohizumi


Book ID
114014592
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
182 KB
Volume
437
Category
Article
ISSN
0014-2999

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Structure-Activity Relationship Studies
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Arylpiperazines represent one of the most studied classes of α1 -adrenoceptor (α1 -AR) antagonists. Currently, α1 -AR antagonists are useful in the treatment of benign prostatic hyperplasia, lower urinary tract symptoms or cardiac arrhythmia. The activity of various derivatives of 1-[3-(4-arylpipera