Rational Design, Synthesis, Biologic Evaluation, and Structure–activity Relationship Studies of Novel 1-Indanone α1-Adrenoceptor Antagonists
✍ Scribed by Minyong Li; Lin Xia
- Book ID
- 111368477
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 224 KB
- Volume
- 70
- Category
- Article
- ISSN
- 1747-0277
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Arylpiperazines represent one of the most studied classes of α1 -adrenoceptor (α1 -AR) antagonists. Currently, α1 -AR antagonists are useful in the treatment of benign prostatic hyperplasia, lower urinary tract symptoms or cardiac arrhythmia. The activity of various derivatives of 1-[3-(4-arylpipera
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Elaborate study on the three-dimensional model of α(1)-adrenoceptor (α(1)-AR) antagonists led to the development of a series of new arylpiperazine derivatives bearing a flavone nucleus as α(1)-AR antagonists. The in vitro activities were evaluated and compounds 1, 4, 10, 13 and 15 showed activities