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Structure–activity relationship studies on a series of cyclohexylpiperazines bearing a phanylacetamide as ligands of the human melanocortin-4 receptor

✍ Scribed by Joseph Pontillo; Joe A. Tran; Nicole S. White; Melissa Arellano; Beth A. Fleck; Dragan Marinkovic; Fabio C. Tucci; John Saunders; Alan C. Foster; Chen Chen


Book ID
108073782
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
126 KB
Volume
15
Category
Article
ISSN
0960-894X

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Structure–activity relationship studies
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## Abstract α~4~β~1~ integrin is a therapeutic target for inflammation, autoimmune diseases, and lymphoid cancers. A series of peptidomimetic ligands based on the Nle‐D‐I motif have been synthesized and their binding affinities (IC~50~) to activated α~4~β~1~ integrin on Jurkat T‐leukemia cells have