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Structure−Activity Relationship of Triazafluorenone Derivatives as Potent and Selective mGluR1 Antagonists

✍ Scribed by Zheng, Guo Zhu; Bhatia, Pramila; Daanen, Jerome; Kolasa, Teodozyj; Patel, Meena; Latshaw, Steven; El Kouhen, Odile F.; Chang, Renjie; Uchic, Marie E.; Miller, Loan


Book ID
115466489
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
307 KB
Volume
48
Category
Article
ISSN
0022-2623

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Virtual Screening for Selective Alloster
✍ Tobias Noeske; Aigars Jirgensons; Igors Starchenkovs; Steffen Renner; Ieva Jaunz 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 667 KB

## Abstract A virtual screening study towards novel noncompetitive antagonists of the metabotropic glutamate receptor 1 (mGluR1) is described. Alignment‐free topological pharmacophore descriptors (CATS) were used to encode the screening compounds. All virtual hits were characterized with respect to