Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists
β Scribed by Kevin G. Liu; Albert J. Robichaud; Alexander A. Greenfield; Jennifer R. Lo; Cristina Grosanu; James F. Mattes; Yanxuan Cai; Guo Ming Zhang; Jean Y. Zhang; Dianne M. Kowal; Deborah L. Smith; Li Di; Edward H. Kerns; Lee E. Schechter; Thomas A. Comery
- Book ID
- 108072946
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 504 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0968-0896
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A series of novel aryl aminosulfonamides was designed and synthesized as 5-HT 6 receptor ligands. Many compounds screened in a functional reporter gene based assay displayed potent antagonistic activity with Kb values in the range of 0.02-10 nM. The lead compound 11m exemplified in this series showe
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