The synthesis of a series of azabicyclic indole esters is described and their potency reported as 5-HT4 receptor antagonists. Optimization of the most potent compound (19) by preparing the corresponding oxazino[3,2-a]indole ester afforded 34, which had a pIC50 of 9.5 in the guinea pig distal colon l
β¦ LIBER β¦
Quinazolindione derivatives as potent 5-HT3A receptor antagonists
β Scribed by Byung-Hwan Lee; Min Jung Choi; Mi Na Jo; Hee Jeong Seo; Seung-Yeol Nah; Yong Seo Cho; Ghilsoo Nam; Ae Nim Pae; Hyewhon Rhim; Hyunah Choo
- Book ID
- 108072634
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 346 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0968-0896
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