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Structure–activity relationship of gramine derivatives in Ca2+ release from sarcoplasmic reticulum

✍ Scribed by Norimichi Nakahata; Yuriko Harada; Makoto Tsuji; Kazumi Kon-ya; Yoshikazu Shizuri; Yasushi Ohizumi

Book ID
114017518
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
141 KB
Volume
382
Category
Article
ISSN
0014-2999

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Ca2+ release from skeletal sarcoplasmic reticulum (SR) could be regulated by at least three mechanisms: 1) Ca2+, 2) calmodulin, and 3) Ca2+/calmodulin-dependent phosphorylation. Bell-shaped Ca(2+)-dependence of Ca2+ release from both actively- and passively-loaded SR vesicles suggest that opening an