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Structure of two new oligosaccharides isolated from human milk: Sialylated lacto-N-fucopentaoses I and II

✍ Scribed by Jean-Michel Wieruszeski; Abdelmalek Chekkor; Stéphane Bouquelet; Jean Montreuil; Gérard Strecker; Jasna Peter-Katalinic; Heinz Egge

Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
660 KB
Volume
137
Category
Article
ISSN
0008-6215

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✦ Synopsis

The structures of two minor oligosaccharides isolated from human milk have been investigated. By using f.a.b.-mass spectrometry, methylation analysis, and partial formolysis as the principal methods of structural investigation, these oligosaccharides were identified as IV2-alpha-Fuc-III6-alpha-NeuAc-LcOse4 and IV3-alpha-NeuAc-III4-alpha-Fuc-LcOse4. This latter oligosaccharide has been recently found to be the carbohydrate moiety of a ganglioside isolated from a colorectal carcinoma cell-line (see ref. 12).

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