Synthesis of methyl (5Z, 8Z, 11Z, 14Z, 1
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Jean-Michel Vatèle; Huynh Dong Doan; Jean-Michel Chardigny; Jean-Louis Sébédio;
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Article
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1994
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Elsevier Science
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English
β 708 KB
3Z,6Z,9Z,12E)-Pentadecatetraenal, a common intermediate in the synthesis of methyl A l7t EPA and methyl A I9t DHA, was obtained by copper(I)-catalyzed coupling between the Grignard reagent of I, 1-diethoxy-3-butyne and (Z, E)l-bromo-5,8-undecadien-2-yne followed by semi-hydrogenation of the resultin