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Structure of the Tribolium castaneum telomerase catalytic subunit TERT

โœ Scribed by Gillis, Andrew J.; Schuller, Anthony P.; Skordalakes, Emmanuel


Book ID
109897687
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
609 KB
Volume
455
Category
Article
ISSN
0028-0836

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Hypermethylation of the human telomerase
โœ Isabelle Guilleret; Pu Yan; Fabienne Grange; Richard Braunschweig; Fred T. Bosma ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 443 KB

DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome