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Structure of the Replicating Complex of a Pol α Family DNA Polymerase

✍ Scribed by Matthew C. Franklin; Jimin Wang; Thomas A. Steitz


Book ID
117268758
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
557 KB
Volume
105
Category
Article
ISSN
0092-8674

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## Abstract A nuclear DNA complex containing DNA polymerase and SV40 T‐antigen was isolated from nuclei of SV40‐transformed mouse fibroblasts. DNA polymerase could be separated from the complex. The remaining DNA/T‐antigen‐containing complex stimulated DNA polymerase a activity about 10‐fold. The c