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Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling

✍ Scribed by Geyer, Matthias; Herrmann, Christian; Wohlgemuth, Sabine; Wittinghofer, Alfred; Kalbitzer, Hans Robert


Book ID
109965137
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
845 KB
Volume
4
Category
Article
ISSN
1072-8368

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Recognition of Ras by its downstream target Raf is mediated by a Rasrecognition region in the Ras-binding domain (RBD) of Raf. Residues 78-89 in this region occupy two different conformations in the ensemble of NMR solution structures of the RBD: a fully ␣-helical one, and one where 87-90 form a typ