The human etherβΓ βgoβgo related gene (hERG) encodes a protein that forms a voltageβgated potassium channel and plays an important role in the heart by controlling the rapid delayed rectifier K^+^ current (__I__~Kr~). The S4βS5 linker was shown to be important for the gating of the hERG channel. Nucl
β¦ LIBER β¦
Structure of the pore-helix of the hERG K+channel
β Scribed by Guilhem Pages; Allan M. Torres; Pengchu Ju; Paramjit S. Bansal; Paul F. Alewood; Philip W. Kuchel; Jamie I. Vandenberg
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 625 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1432-1017
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## Abstract ERG potassium channels specify one component of the delayed rectifier in the heart and are likely to play an important functional role in other excitable cells. Compared to other K^+^ channels, the human ERG (hERG) channel possesses an unusually long S5βP linker that presumably forms an
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