Structure of the 2:1 adduct of dimethyl acetylenedicarboxylate and dehydronuciferine: a novel tandem michael-1,3-dipolar addition reaction
β Scribed by Mary D. Menachery; Patrick Carroll; Michael P. Cava
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 121 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The 1,4-dipolar intermediate generated by the addition of isoquinoline to dimethyl acetylenedicarboxylate is trapped by 1,2-and 1,4-benzoquinones to afford spiro[1,3]oxazino[2,3-a]isoquinoline derivatives in high yields.
## Abstract An efficient synthesis of [1,3]oxazino[3,2β__f__]phenanthridine derivatives __via__ a threeβcomponent reaction of phenanthridine, dimethyl acetylenedicarboxylate (DMAD), and aromatic aldehydes is described. This novel method is complementary to the classical __Huisgen__ 1,4βdipolar cycl