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Structure of stereochemistry of thysanone: a novel human rhinovirus 3C-protease inhibitor from Thysanophora penicilloides

✍ Scribed by Sheo B. Singh; Michael G. Cordingley; Richard G. Ball; Jack L. Smith; Anne W. Dombrowski; Michael A. Goetz

Publisher: Elsevier Science
Year: 1991
Tongue: French
Weight: 248 KB
Volume: 32
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)92364-5

No coin nor oath required. For personal study only.

✦ Synopsis

The structure of thysanone (la). a novel naphthoquinone with a lactol ring was established on the basis of ID and 20 NiUR spectroscopy and confirmed by X-ray crystallogr@ic analysis of the monomethyl ether (lb). Thysanone showed an ICJO of 13 pghnL against HRV 3C-protease.

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