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Structure of oxidatively damaged nucleic acid adducts: PH dependence of the 13C NMR spectra of 8-oxoguanosine and 8-oxoadenosine

✍ Scribed by Bongsup P. Cho

Book ID: 102526855
Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 487 KB
Volume: 31
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1260311204

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✦ Synopsis

Abstract

^13^C NMR spectra of two C‐8‐oxo purine nucleosides, 8‐oxoguanosine and 8‐oxoadenosine, were recorded as a function of pH. The pH dependence of ^13^C chemical shifts and ^13^C‐^1^H coupling constants associated with the purine carbon resonances was analyzed to probe the sites and extent of ionization and protonation of these oxidatively damaged nucleic acid adducts. In the course of this study, it was found that the C‐2′ and C‐3′ resonances of the ribofuranosyl sugar ring can be conveniently assigned on the basis of their unique pH‐independent ^1^H‐coupling spectral patterns in aqueous solution.

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