In this study, (5a,7a)-4,5-epoxy-3,6-dimethoxy-17-methyl-6,14-ethenomorphinan-7-carboxylic acid hydrazide (5) was synthesized by the condensation of methyl (5a,7a)-4,5-epoxy-3,6-dimethoxy-17methyl-6,14-ethenomorphinan-7-carboxylate (4) with NH 2 NH 2 • H 2 O. The (5a,7a)-4,5-epoxy-3,6-dimethoxy-17-m
Structure of N-(3,6-dimethoxy-17-methyl-4,5-epoxy-6,14α-etheno-7α-isomorphinanylcarbonyl)-l-phenylalanine ethyl ester hydrochloride
✍ Scribed by Spek, A. L. ;Cappon, J. J. ;Lie, T. S. ;Maat, L.
- Book ID
- 114507394
- Publisher
- International Union of Crystallography
- Year
- 1990
- Tongue
- English
- Weight
- 460 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0108-2701
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## Abstract In a limited number of cases, 14‐alkenylcodeinones (=14‐alkenyl‐7,8‐didehydro‐4,5‐epoxy‐3‐methoxy‐17‐methylmorphinan‐6‐ones) can be obtained by formic acid treatment of thevinols (=4,5‐epoxy‐3,6‐dimethoxy‐__α__,17‐dimethyl‐6,14‐ethenomorphinan‐7‐methanols), but under these conditions th
The oxidation of thebdine (5) under the same conditions gave 14-hydroxycodeinone (7) in similar yields.
## 9. VIII.93) Nucleophilic substitution of 6p-chloro-7,8-didehydro-4,5~ -epoxy-3-methoxy-17-rnethylmorphinan (1) and 8a -brom0-6,7-didehydro-4,5~ -epoxy-3-methoxy-17-methylmorphinan (2) with lithium cyano(methy1)-and (aryl)cyanocuprates(I) (5a-c) was accompanied by allylic rearrangement with both