Synthesis, Structure Elucidation, and Pharmacological Evaluation of 5-Methyl-oxymorphone (= 4,5α-epoxy-3,14-dihydroxy-5,17-dimethylmorphinan-6-one)
✍ Scribed by Helmut Schmidhammer; Jack B. Deeter; Noel D. Jones; J. David Leander; Darryle D. Schoepp; John K. Swartzendruber
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- German
- Weight
- 243 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
The oxidation of thebdine (5) under the same conditions gave 14-hydroxycodeinone (7) in similar yields.
📜 SIMILAR VOLUMES
## Abstract Fusion of an azole moiety at C‐6 and C‐7 of naltrexone (1) is illustrated by the synthesis of the title compound 8. Bromination of 3‐__O__‐methylnaltrexone led to the 1,7α‐dibromo derivative which reacted with thiourea to attach the 2‐aminothiazole ring to C‐6 and C‐7 of naltrexone. Aft
In this study, (5a,7a)-4,5-epoxy-3,6-dimethoxy-17-methyl-6,14-ethenomorphinan-7-carboxylic acid hydrazide (5) was synthesized by the condensation of methyl (5a,7a)-4,5-epoxy-3,6-dimethoxy-17methyl-6,14-ethenomorphinan-7-carboxylate (4) with NH 2 NH 2 • H 2 O. The (5a,7a)-4,5-epoxy-3,6-dimethoxy-17-m
## Abstract In a limited number of cases, 14‐alkenylcodeinones (=14‐alkenyl‐7,8‐didehydro‐4,5‐epoxy‐3‐methoxy‐17‐methylmorphinan‐6‐ones) can be obtained by formic acid treatment of thevinols (=4,5‐epoxy‐3,6‐dimethoxy‐__α__,17‐dimethyl‐6,14‐ethenomorphinan‐7‐methanols), but under these conditions th