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Structure of Microcin J25, a Peptide Inhibitor of Bacterial RNA Polymerase, is a Lassoed Tail.

✍ Scribed by Kelly-Anne Wilson; Markus Kalkum; Jennifer Ottesen; Julia Yuzenkova; Brian T. Chait; Robert Landrick; Tom Kuir; Konstantin Severinov; Seth A. Darst

Publisher: John Wiley and Sons
Year: 2004
Weight: 54 KB
Volume: 35
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200404157

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## Abstract Microcin J25 is a potent antibacterial peptide produced by __Escherichia coli__ AY25. It displays a lasso structure, which consists of a knot involving an N‐terminal macrolactam ring through which the C‐terminal tail is threaded and sterically trapped. In this study, we rationally desig