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Structure of Aldehyde Reductase Holoenzyme in Complex with the Potent Aldose Reductase Inhibitor Fidarestat: Implications for Inhibitor Binding and Selectivity

✍ Scribed by El-Kabbani, Ossama; Carbone, Vincenzo; Darmanin, Connie; Oka, Mitsuru; Mitschler, Andre; Podjarny, Alberto; Schulze-Briese, Clemens; Chung, Roland P.-T.


Book ID
120448137
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
285 KB
Volume
48
Category
Article
ISSN
0022-2623

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Studies on the inhibitor-binding site of
✍ Ossama El-Kabbani; Deborah A. Carper; Michelle H. McGowan; Yancho Devedjiev; Kar πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 216 KB πŸ‘ 2 views

Aldehyde reductase is an enzyme capable of metabolizing a wide variety of aldehydes to their corresponding alcohols. The tertiary structures of aldehyde reductase and aldose reductase are similar and consist of an alpha/beta-barrel with the active site located at the carboxy terminus of the strands