✦ LIBER ✦

High-Resolution Structures of Human Aldose Reductase Holoenzyme in Complex with Stereoisomers of the Potent Inhibitor Fidarestat: Stereospecific Interaction between the Enzyme and a Cyclic Imide Type Inhibitor

✍ Scribed by El-Kabbani, Ossama; Darmanin, Connie; Oka, Mitsuru; Schulze-Briese, Clemens; Tomizaki, Takashi; Hazemann, Isabelle; Mitschler, Andre; Podjarny, Alberto

Book ID: 127006273
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 361 KB
Volume: 47
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm0497794

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Structure of Aldehyde Reductase Holoenzy

Structure of Aldehyde Reductase Holoenzyme in Complex with the Potent Aldose Reductase Inhibitor Fidarestat: Implications for Inhibitor Binding and Selectivity

✍ El-Kabbani, Ossama; Carbone, Vincenzo; Darmanin, Connie; Oka, Mitsuru; Mitschler 📂 Article 📅 2005 🏛 American Chemical Society 🌐 English ⚖ 285 KB

Unusual Binding Mode of the 2 S 4 R Ster

Unusual Binding Mode of the 2 S 4 R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2 S 4 S ) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 Å Resolution: Implications for the Inhibition Mechanism

✍ Zhao, Hai-Tao; Hazemann, Isabelle; Mitschler, Andre; Carbone, Vincenzo; Joachimi 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 693 KB