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Structure of ACC synthase inactivated by the mechanism-based inhibitor l-vinylglycine

✍ Scribed by Guido Capitani; Markus Tschopp; Andrew C. Eliot; Jack F. Kirsch; Markus G. Grütter


Book ID
118441932
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
298 KB
Volume
579
Category
Article
ISSN
0014-5793

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Design, Synthesis, and Evaluation of the First Mechanism-Based Inhibitor of Glucosamine 6-Phosphate Synthase. -The first example of the title inhibitor, the compound (I), a glutamine derivative bearing a latent electrophilic function, is prepared starting from suitably protected glutamine. (I) is st