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Structure of a c-Cbl–UbcH7 Complex: RING Domain Function in Ubiquitin-Protein Ligases

✍ Scribed by Ning Zheng; Ping Wang; Philip D. Jeffrey; Nikola P. Pavletich


Book ID
117266986
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
417 KB
Volume
102
Category
Article
ISSN
0092-8674

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Structure of a c-Cbl–UbcH7 Complex: RING
✍ Ning Zheng; Ping Wang; Philip D. Jeffrey; Nikola P. Pavletich 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 417 KB

proto-oncogene that regulates the p53 tumor suppressor (Fang et al., 2000), and members of the IAP family Ubiquitin-protein ligases (E3s) regulate diverse celluof antiapoptotic proteins (Yang et al., 2000). lar processes by mediating protein ubiquitination. The The c-Cbl protein attenuates signaling