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Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine

✍ Scribed by Marieke B.A.C Lamers; Alfred A Antson; Roderick E Hubbard; Richard K Scott; David H Williams


Book ID
115628983
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
824 KB
Volume
285
Category
Article
ISSN
0022-2836

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Conformational searches on three closely related pp60 c-src protein tyrosine kinase inhibitors of varying potencies were performed to determine a structural basis for their activity. The first was a linear peptide (PDNEYAFFQf), the second its 10-membered cyclic analogue, and the third a cyclic analo