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Structure of (3R,4S)-1-(p-bromobenzoyl)-3-[(R)-1-hydroxyethyl]-4-trimethylsilylethynyl-2-azetidinone

✍ Scribed by Tada, T. ;Koda, S. ;Morimoto, Y. ;Chiba, T. ;Nakai, T.


Book ID
114505213
Publisher
International Union of Crystallography
Year
1987
Tongue
English
Weight
324 KB
Volume
43
Category
Article
ISSN
0108-2701

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Stereoselective synthesis of (1β€²S,3R,4R)
✍ Ivan Plantan; Michel Stephan; UroΕ‘ Urleb; Barbara Mohar πŸ“‚ Article πŸ“… 2009 πŸ› Elsevier Science 🌐 French βš– 218 KB

A stereoselective synthesis of (1 0 S,3R,4R)-4-acetoxy-3-(2 0 -fluoro-1 0 -trimethylsilyloxyethyl)-2-azetidinone as a new fluorine-containing intermediate towards b-lactams, is described. The synthetic key step relies upon the dynamic kinetic resolution (DKR) of ethyl 2-benzamidomethyl-4-fluoro-3-ox