Structure, Function, and Modulation of Neuronal Voltagegated Ion Channels

Year: 2009
Tongue: English
Leaves: 488
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.Content:
Chapter 1 Neuronal L?Type Voltage?Gated Calcium Channels (pages 1–34): Alexander Scriabine and David J. Triggle
Chapter 2 Voltage?Gated N?Type and T?Type Calcium Channels and Excitability Disorders (pages 35–66): Elizabeth Tringham and Terrance P. Snutch
Chapter 3 Voltage?Gated Sodium Channels: Multiple Roles in the Pathophysiology of Pain (pages 67–104): Sulayman D. Dib?Hajj, Bryan C. Hains, Joel A. Black and Stephen G. Waxman
Chapter 4 The Role of Ion Channels in the Etiology and Development of Gliomas (pages 105–126): Amy K. Weaver and Harald Sontheimer
Chapter 5 Shaker Family Kv1 Voltage?Gated Potassium Channels in Mammalian Brain Neurons (pages 127–154): Helene Vacher and James S. Trimmer
Chapter 6 Unique Mitochondrial Ion Channels: Roles in Synaptic Transmission and Programmed Cell Death (pages 155–191): Elizabeth A. Jonas
Chapter 7 Regulation of Neuronal Excitability by the Sodium?Activated Potassium Channels Slick (SLO2.1) and Slack (SLO2.2) (pages 193–215): Valentin K. Gribkoff and Leonard K. Kaczmarek
Chapter 8 Alternative Splicing of Neuronal Cav2 Calcium Channels (pages 217–250): Diane Lipscombe, Summer E. Allen, Annette C. Gray, Spiro Marangoudakis and Jesica Raingo
Chapter 9 Effect of Hypoxia/Ischemia on Voltage?Dependent Channels (pages 251–277): Xiang Q. Gu, Hang Yao and Gabriel G. Haddad
Chapter 10 In Vivo Roles of Ion Channel Regulatory Protein Complexes in Neuronal Physiology and Behavior (pages 279–289): Smitha Reddy, Mohammad Shahidullah and Irwin B. Levitan
Chapter 11 Regulation of Neuronal Ion Channels by G?Protein?Coupled Receptors in Sympathetic Neurons (pages 291–316): Mark S. Shapiro and Nikita Gamper
Chapter 12 BK Channels: Regulation of Expression and Physiological Impact (pages 317–342): Pallob Kundu, Abderrahmane Alioua, Yogesh Kumar, Rong Lu, Jimmy W. Ou, Enrique Sanchez?Pastor, Min Li, Enrico Stefani and Ligia Toro
Chapter 13 Structural Basis for Auxiliary KChIP Modulation of Kv4 Channels (pages 343–361): KeWei Wang and Jijie Chai
Chapter 14 Sodium Channel Blockers for the Treatment of Chronic Pain (pages 363–391): Mark R. Bowlby and Edward Kaftan
Chapter 15 Neuronal Kv7 Potassium Channels as Emerging Targets for the Treatment of Pain (pages 393–421): Steven I. Dworetzky and Valentin K. Gribkoff
Chapter 16 Small?Molecule Modulators of Large?Conductance, Calcium?Activated (BK) Channels (pages 423–441): John E. Starrett
Chapter 17 High?Throughput Screening Technologies in Ion Channel Drug Discovery (pages 443–466): Edward B. Stevens, Andrew D. Whyment and J. Mark Treherne

📜 SIMILAR VOLUMES

Structure, Function and Modulation of Ne

📁 Structure, Function and Modulation of Neuronal Voltage-Gated Ion Channels

✍ Valentin K. Gribkoff, Leonard K. Kaczmarek 📂 Library 📅 2009 🌐 English

Potassium Ion Channels Molecular Structu

📁 Potassium Ion Channels Molecular Structure, Function, and Diseases

✍ Yoshihisa Kurachi, Lily Yeh Jan and Michel Lnzdunski (Eds.) 📂 Library 📅 1999 🏛 Academic Press 🌐 English

This book is the first to focus on potassium ion channels and covers the recent remarkable progress made in research on these proteins. Many diseases are caused by the abnormalities of potassium ion channels. They include diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, n

Voltage-gated Sodium Channels: Structure

📁 Voltage-gated Sodium Channels: Structure, Function and Channelopathies

✍ Mohamed Chahine 📂 Library 📅 2018 🏛 Springer International Publishing 🌐 English

<p><p>This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pa

The Oxford Handbook of Neuronal Ion Chan

📁 The Oxford Handbook of Neuronal Ion Channels

✍ Arin Bhattacharjee 📂 Library 📅 2023 🏛 Oxford University Press 🌐 English

<span>Neurons are excitable cells. They use ions and electrical signaling to talk to each to other and when they talk to each other, neurons control behavior. The Oxford Handbook of Neuronal Ion Channels is an accessible reference describing the nature and properties of ion channels in neurons. The

The Oxford Handbook of Neuronal Ion Chan

📁 The Oxford Handbook of Neuronal Ion Channels

✍ Arin Bhattacharjee 📂 Library 📅 2022 🌐 English

The Oxford Handbook of Neuronal Ion Chan

📁 The Oxford Handbook of Neuronal Ion Channels

✍ Arin Bhattacharjee 📂 Library 📅 2023 🏛 Oxford University Press 🌐 English

Neurons are excitable cells. They use ions and electrical signaling to talk to each to other and when they talk to each other, neurons control behavior. The Oxford Handbook of Neuronal Ion Channels is an accessible reference describing the nature and properties of ion channels in neurons. The book e