## Class I1 major histocompatibility complex-restricted T cell function in CD4deficient mice* Previously, we and others have demonstrated that CD4-deficient mice have a normal number of Tcells and B cells with a significant population of CD4-8-TcRaP+ T cells. Surprisingly, however, these mice lack
Structure function analysis of in vitro mutated CD4 and major histocompatibility complex class II gene products
β Scribed by McCluskey, James; Kjer-Nielsen, Lars; Blok, Rozanne
- Book ID
- 122543871
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 639 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0896-8411
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The activation requirements for antigen-dependent proliferation of CD4+ T cells are well documented,while the events leading to the inactivation phase are poorly understood. Here, we tested the hypothesis that the lymphocyte-activation gene 3 (LAG-3), a second major histocompatibility complex (MHC)
## Communicated by Henrik Dahl MHC class II deficiency is a severe primary immunodeficiency characterised by the absence of major histocompatibility complex class II (MHC-II) gene expression. It is genetically heterogeneous and can result from defects in at least four different trans-acting regula