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Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice

✍ Scribed by Amin Rahemtulla; Thomas M. Kündig; Arumugabadiv Narendran; Martin F. Bachmann; Michael Julius; Christopher J. Paige; Pamela S. Ohashi; Rolf M. Zinkernagel; Tak W. Mak

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
715 KB
Volume
24
Category
Article
ISSN
0014-2980

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✦ Synopsis

Class I1 major histocompatibility complex-restricted T cell function in CD4deficient mice*

Previously, we and others have demonstrated that CD4-deficient mice have a normal number of Tcells and B cells with a significant population of CD4-8-TcRaP+ T cells. Surprisingly, however, these mice lacking CD4 show in vivo immunoglobulin isotype class switching from IgM to IgG in response to sheep erythrocytes and vesicular stomatitis virus. In this study we have depleted various subpopulations of T cells in vivo and shown that the population of CD4-8-TcRaP+ T cells is responsible for providing "help" in the antibody response of CDCdeficient mice to vesicular stomatitis virus infection. We have used antigen-specific proliferation assays and blocking studies with class I and I1 major histocompatibility complex (MHC)-specific purified antibodies to show that these cells are class I1 MHC-restricted in responses against the T celldependent antigen keyhole limpet hemocyanin (KLH). Finally, phenotypic analysis of the CD4-CD8-thymocytes in CD4-deficient mice shows that these cells have a more mature phenotype than the CD4-8-thymocytes in wild type mice. These results indicate that CD4 is not absolutely necessary for positive selection or effector function of class I1 MHC-restricted helper T cells.

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