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Increased number of cytotoxic T cells within CD4+8− T cells in β2-microglobulin, major histocompatibility complex class I-deficient mice

✍ Scribed by Suzana Marušić-Galešić; Keiko Udaka; Peter Walden

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
509 KB
Volume
23
Category
Article
ISSN
0014-2980

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✦ Synopsis

Increased number of cytotoxic T cells within CD4+8-T cells in P2-microglobulin, major histocompatibility complex class I-deficient mice*

Targeted disruption of fi2-microgobulin gene results in deficient major histocompatibility complex class I expression and failure to develop CD4-V T cells. Despite this, fi2M-/-mice reject skin grafts and cope with most viral infections tested. We asked whether CD4+8-cytotoxic T cells could play a role in compensating for the defect in CD4-8+ cytotoxic T cell function. We found that the cytotoxic activity against class 11+ targets is significantly higher among CD4+8-T cells of fi2M-I-than among those of fizM+I+ mice. In the limiting dilution experiment, we showed that the precursor frequency for the cytotoxic, CD4+8-, class 11-specific T cells is at least fivefold higher in P2M-I-than in P2M+/+ mice. These results suggest that CD4+8-cytotoxic T cells could play a major role in carrying out cytotoxic function in fi2M-I-mice.

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