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Structure elucidation of thermal degradation products of amlodipine

✍ Scribed by A. Siva Lakshmi Devi; Y. Srinivasa Rao; M. Satish; G. Jyothi; K. Babu Rao; T. Omdutt

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
154 KB
Volume
45
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

Thermal degradation of amlodipine base causes intramolecular reactions affording three cyclic products, referred to as AMLDEG‐I, AMLDEG‐II, and AMLDEG‐III, respectively. AMLDEG‐I is a cyclized product formed by intramolecular elimination of ammonia from amlodipine. AMLDEG‐II is a positional isomer of AMLDEG‐I. AMLDEG‐III is also intramolecular cyclisation product. The three degradation products were isolated by column chromatography and characterized by FT‐IR and ^1^H and ^13^C NMR spectroscopy data. The AMLDEG‐III was crystallized and its structure was solved by single crystal X‐ray diffraction (SXRD). Copyright © 2007 John Wiley & Sons, Ltd.

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