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Structure determinants of substrate specificity of hydroxynitrile lyase from Manihot esculenta

✍ Scribed by Hanspeter Lauble; Burkhard Miehlich; Siegfried Förster; Christoph Kobler; Harald Wajant; Franz Effenberger

Book ID
111753347
Publisher
Cold Spring Harbor Laboratory Press
Year
2009
Tongue
English
Weight
468 KB
Volume
11
Category
Article
ISSN
0961-8368

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Inversion of Stereoselectivity by Applying Mutants of the Hydroxynitrile Lyase from Manihot esculenta
✍ Holger Bühler; Burkhard Miehlich; Franz Effenberger 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 216 KB

## Abstract __The influence of Trp128‐substituted mutants of the hydroxynitrile lyase from__ Manihot esculenta __(MeHNL) on the stereoselectivity of MeHNL‐catalyzed HCN additions to aldehydes with stereogenic centers, which yield the corresponding cyanohydrins, is described. In__ rac__‐2‐phenylprop