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Structure-Based Pharmacophore Design and Virtual Screening for Novel Angiotensin Converting Enzyme 2 Inhibitors

✍ Scribed by Rella, Monika; Rushworth, Christopher A.; Guy, Jodie L.; Turner, Anthony J.; Langer, Thierry; Jackson, Richard M.

Book ID
117995564
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
374 KB
Volume
46
Category
Article
ISSN
0095-2338

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## Abstract Protein kinase CK2, a member of the serine/threonine kinase family, is an attractive therapeutic target for anticancer combination therapy. A multiple structure‐based modeling approach complemented with shape components was taken to build a reliable pharmacophore model for ATP‐competiti