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Design of Angiotensin-converting Enzyme 2 (ACE2) Inhibitors by Virtual Lead Optimization and Screening

✍ Scribed by Juan E. Torres; Rosa Baldiris; Ricardo Vivas-Reyes

Book ID
115558632
Publisher
Chinese Electronic Periodical Services
Year
2012
Tongue
English
Weight
773 KB
Volume
59
Category
Article
ISSN
0009-4536

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## Abstract In spite of the important role of angiotensin converting enzyme 2 (ACE2) in the cardiovascular system, little is known about the substrate structural requirements of the AngII–ACE2 interaction. Here we investigate how changes in angiotensin II (AngII) structure affect binding and cleava