𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Structure-Based Optimization of Phenylbutyrate-Derived Histone Deacetylase Inhibitors

✍ Scribed by Lu, Qiang; Wang, Da-Sheng; Chen, Chang-Shi; Hu, Yuan-Dong; Chen, Ching-Shih

Book ID
126808724
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
319 KB
Volume
48
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Novel Sulfonamide Derivatives as Inhibit
Novel Sulfonamide Derivatives as Inhibitors of Histone Deacetylase
✍ Paulβ€…W. Finn; Morwena Bandara; Chris Butcher; Angela Finn; Ruth Hollinshead; Nag πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 German βš– 374 KB

## Abstract Inhibition of the enzyme histone deacetylase (HDAC) is emerging as a novel approach to the treatment of cancer. A series of novel sulfonamide derivatives were synthesized and evaluated for their ability to inhibit human HDAC. Compounds were identified which are potent enzyme inhibitors,

Synthesis of side chain modified apicidi
Synthesis of side chain modified apicidin derivatives: potent mechanism-based histone deacetylase inhibitors
✍ Peter T Meinke; Steven L Colletti; Michelle B Ayer; Sandra J Darkin-Rattray; Rob πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 87 KB

An efficient degradation of apicidin's ketone-containing side chain to two common intermediates (the C7-aldehyde and the C8-methyl ester) is described. From these intermediates, a series of potent mechanism-based histone deacetylase inhibitors was prepared to facilitate biochemical studies.