Structure-Based Design, Synthesis, and Evaluation of 2′-(2-Hydroxyethyl)-2′-deoxyadenosine and the 5′-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors
✍ Scribed by Dianqing Sun; Hai Xu; Sanath R. Wijerathna; Chris Dealwis; Richard E. Lee
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 538 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1860-7179
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical