ChemInform Abstract: Synthesis of 2′-Thiouridine and -cytidine Derivatives as Potential Inhibitors of Ribonucleoside Diphosphate Reductase: Thionitrites, Disulfides and 2′-Thiouridine 5′-Diphosphate.
✍ Scribed by L. LE HIR DE FALLOIS; J.-L. DECOUT; M. FONTECAVE
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 37 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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Synthesis of 5-[(Indol-2-on-3-yl)methyl]-2,2-dimethyl-1,3-dioxane-4,6diones and Spirocyclopropyloxindole Derivatives. Potential Aldose Reductase Inhibitors. -Indoles (I) are transformed into indolyl derivatives (IV) following a literature process. Subsequent reaction with 1 equiv. of NBS generates